BIopsies of KnEejoint synovitis from RA or OA patients

project manager


phd fellow

About the project

A pilot study of ultrasound-guided biopsies (tissue samples) of synovitis (inflamed synovium) in the knee joint from patients with rheumatoid arthritis or osteoarthritis who come to the outpatient clinic at Diakonhjemmet Hospital due to swelling of the knee. The study is a methodological study to develop a good technical way to perform biopsies in the knee joint in addition to mapping the immunological cells in the biopsies and comparing biopsies from patients with inflammatory or degenerative knee disease.

Internationally, many centers perform ultrasound-guided biopsies of synovitis from both large and small joints. In Norway, this is the first study using this method.

The purpose of the study is to establish good methods for taking biopsies, as it is expected that this will be important in the future to identify which drug treatments the individual patient should have

Who can participate?

Patients aged 18 years and older with rheumatoid arthritis (arthritis) or osteoarthritis.

Recruitment of participants for the study is ongoing.

Project arrangement

A biopsy needle that is only slightly thicker than a normal needle for joint puncture is used under local anaesthesia. A local anaesthetic is injected into the joint cavity and then biopsies/tissue samples are taken from the synovium (the inflamed synovium). If a cortisone injection is needed, the cortisone is injected through the same needle after the biopsies have been taken.


All rights reserved © REMEDY; Illustration/portrait images © Nicolas Tourrenc/Diakonhjemmet Hospital