Education

Cand.med., University of Oslo (professional study in medicine)
Master of Public Health, Harvard School of Public Health
Doctorate at the Department of Clinical Medicine, University of Oslo

Position

Deputy Director, Research Center for Treatment in Rheumatology and Musculoskeletal Diseases (REMEDY), Diakonhjemmet Hospital
Head of the Clinical Research Unit, Diakonhjemmet Hospital
Associate Professor, Department of Health and Society, University of Oslo

Field of interest

Clinical studies in orthopedics and rheumatology with a special focus on randomized-controlled trials

Other

Leader of work package 1 in REMEDY (Treatment studies)
Recipient of the Marie Spångberg Prize 2022

Email

This email address is protected from spambots. You need JavaScript enabled to view it.

Telephone

Visiting address

Diakonhjemmet Hospital
Superintendent's residence
Reidar Kobros vei 8
0370 Oslo

Postal address

Diakohjemmet Hospital
PO Box 23 Vinderen
0319 Oslo

Projects

WP1 - Optimized medical interventions

ARCTIC

Remission in patients with rheumatoid arthritis: a randomized controlled trial investigating the use of ultrasound in clinical follow-up

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WP1 - Optimized medical interventions

ARCTIC FORWARD

10-year follow-up of patients with rheumatoid arthritis who received structured treatment-to-target therapy in the early phase of the disease.

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WP1 - Optimized medical interventions

ARCTIC REWIND

Study on tapering treatment in rheumatoid arthritis without loss of disease control.

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WP1 - Optimized medical interventions

ARCTIC REWIND extension study

Long-term follow-up of patients with well-controlled rheumatoid arthritis - the ARCTIC REWIND extension study

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WP1 - Optimized medical interventions

HIFSAT

Study of surgical approach to hip fracture

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WP1 - Optimized medical interventions

MethMax

Maximizing treatment effect

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WP2 - PPhenotyping for personalized medicine

MoRA – monitoring aspects of rheumatoid arthritis

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WP1 - Optimized medical interventions

NOR-CACTUS

Comparison of treatment strategies for carpal tunnel syndrome

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WP5 - Innovative approaches to remote care

NOR-Flare

Remote follow-up of patients with rheumatoid arthritis

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WP1 - Optimized medical interventions

NOR Sprint

Follow-up of newly diagnosed patients with psoriatic arthritis with and without imaging

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WP5 - Innovative approaches to remote care

OA-AID

Digital coping tools and digital follow-up for patients with knee osteoarthritis

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WP1 - Optimized medical interventions

SQUEEZE

Maximizing the effectiveness of prescription drugs for rheumatoid arthritis

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Publications

Publications retrieved from the National Science Archives (NVA):

Development of Machine Learning Models for Predicting Non-Remission in Early RA Highlights the Robust Predictive Importance of the RAID Score-Evidence from the ARCTIC Study

2025

Longitudinal risk of serious infections in patients with inflammatory arthritis on immunomodulating therapy compared to controls

2025

Predictors of 1-year mortality in a clinical cohort of hip fracture patients

2025

Short-Term Clinical and Radiological Results of the Infinity Ankle Arthroplasty: A Prospective Study

2025

Remote monitoring or patient-initiated care in axial spondyloarthritis: a 3-armed randomized controlled noninferiority trial

2025

Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis

2025

Three-Year Results of Tapering Tumor Necrosis Factor Inhibitor to Withdrawal Compared to Stable Tumor Necrosis Factor Inhibitor Among Patients With Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial

2025

Effects of tapering conventional synthetic disease-modifying antirheumatic drugs to drug-free remission versus stable treatment in rheumatoid arthritis (ARCTIC REWIND): 3-year results from an open-label, randomized controlled, non-inferiority trial

2024

Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity

2024

Use of direct-acting anticoagulants (DOACs) delays surgery and is associated with increased mortality in hip fracture patients

2024

Five-Year Results of the Salto XT Revision Ankle Arthroplasty

2024

Agreement between patient-reported flares and clinically significant flare status in patients with rheumatoid arthritis in sustained remission: data from the ARCTIC REWIND trials

2024

Follow-Up of Patients With Axial Spondyloarthritis in Specialist Health Care With Remote Monitoring and Self-Monitoring Compared With Regular Face-to-Face Follow-Up Visits (the ReMonit Study): Protocol for a Randomized, Controlled Open-Label Noninferiority Trial

2023

Effect of tapered versus stable treatment with tumor necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial

2023

Discontinuation of Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis and Excellent Disease Control

2023

Rheumatology congresses post COVID-19: we cannot regress

2023

Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis

2022

All-cause and cause-specific mortality in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: a nationwide registry study

2022

Inflammation and biologic therapy in patients with rheumatoid arthritis achieving versus not achieving ACR/EULAR Boolean remission in a treat-to-target study

2022

Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment

2021

Serious infections in patients with rheumatoid arthritis and psoriatic arthritis treated with tumor necrosis factor inhibitors: data from register linkage of the NOR-DMARD study

2021

Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients with Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial

2021

MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients

2021

Value of MRI and ultrasound for prediction of therapeutic response and erosive progression in patients with early rheumatoid arthritis managed by an aggressive treat-to-target strategy

2021

Conventional versus ultrasound treat to target: No difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis

2020

Achievement of Remission in Two Early Rheumatoid Arthritis Cohorts Implementing Different Treat-to-Target Strategies

2020

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells

2020

Trends in All-Cause and Cardiovascular Mortality in Patients With Incident Rheumatoid Arthritis: A 20-year Follow-Up Matched Case-Cohort Study

2019

Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)

2019

Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis

2019

Subclinical treatment targets in rheumatology: Lessons from randomized clinical trials in rheumatoid arthritis

2019

Immunosuppressive treatment and the risk of diabetes in rheumatoid arthritis

2019

Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial

2018

Predictors of sustained remission in patients with early rheumatoid arthritis treated according to an aggressive treat-to-target protocol

2018

The impact of ultrasound on the use and efficacy of intraarticular glucocorticoid injections in early rheumatoid arthritis: Secondary analyzes from a randomized trial examining the benefit of ultrasound in a clinical tight control regimen

2018

The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy

2018

Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: Associations to future good radiographic and physical outcomes

2018

The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group

2017

Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis

2017

Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria

2017

Ultrasound in the management of rheumatoid arthritis: ARCTIC randomized controlled strategy trial

2016

Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach

2016

Validation of the OMERACT magnetic resonance imaging joint space narrowing score for the wrist in a multireader longitudinal trial

2015

The OMERACT MRI in arthritis working group - Update on status and future research priorities

2015

Rheumatoid arthritis quality measures and radiographic progression

2014

Update on the OMERACT Magnetic Resonance Imaging Task Force: Research and Future Directions

2014

Iterative development and reliability of the OMERACT Hand Osteoarthritis MRI Scoring System

2014

The OMERACT-RAMRIS Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing Score: Intrareader and Interreader Reliability and Agreement with Computed Tomography and Conventional Radiography

2013

Performance of Matrix-Based Risk Models for Rapid Radiographic Progression in a Cohort of Patients With Established Rheumatoid Arthritis

2013

What is the clinical relevance of erosions and joint space narrowing in RA?

2012

Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort

2012

Should modern imaging be part of remission criteria in rheumatoid arthritis?

2012

Update on Research and Future Directions of the OMERACT MRI Inflammatory Arthritis Group

2011

Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System

2011

The OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) Is Reliable and Sensitive to Change: Results from an OMERACT Workshop

2011

Hand osteoarthritis and MRI: development and first validation step of the proposed Oslo Hand Osteoarthritis MRI score

2011

Comparison of utility measures and their relationship with other health status measures in 1041 patients with rheumatoid arthritis

2010

Siri Lillegraven

Education

Position

Field of interest

Other

Email

Telephone

Visiting address

Postal address

Projects

Publications

Publications retrieved from the National Science Archives (NVA):

Development of Machine Learning Models for Predicting Non-Remission in Early RA Highlights the Robust Predictive Importance of the RAID Score-Evidence from the ARCTIC Study

Longitudinal risk of serious infections in patients with inflammatory arthritis on immunomodulating therapy compared to controls

Predictors of 1-year mortality in a clinical cohort of hip fracture patients

Short-Term Clinical and Radiological Results of the Infinity Ankle Arthroplasty: A Prospective Study

Remote monitoring or patient-initiated care in axial spondyloarthritis: a 3-armed randomized controlled noninferiority trial

Recognition of Glycine Versus Nonglycine Citrulline Motifs Dictating the HLA Class II Association of Anticitrullinated Protein Antibodies: Insights From Autoantibody Profiling of 6,900 Scandinavian Patients With Rheumatoid Arthritis

Three-Year Results of Tapering Tumor Necrosis Factor Inhibitor to Withdrawal Compared to Stable Tumor Necrosis Factor Inhibitor Among Patients With Rheumatoid Arthritis in Sustained Remission: A Multicenter Randomized Trial

Effects of tapering conventional synthetic disease-modifying antirheumatic drugs to drug-free remission versus stable treatment in rheumatoid arthritis (ARCTIC REWIND): 3-year results from an open-label, randomized controlled, non-inferiority trial

Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity

Use of direct-acting anticoagulants (DOACs) delays surgery and is associated with increased mortality in hip fracture patients

Five-Year Results of the Salto XT Revision Ankle Arthroplasty

Agreement between patient-reported flares and clinically significant flare status in patients with rheumatoid arthritis in sustained remission: data from the ARCTIC REWIND trials

Follow-Up of Patients With Axial Spondyloarthritis in Specialist Health Care With Remote Monitoring and Self-Monitoring Compared With Regular Face-to-Face Follow-Up Visits (the ReMonit Study): Protocol for a Randomized, Controlled Open-Label Noninferiority Trial

Effect of tapered versus stable treatment with tumor necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial

Discontinuation of Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis and Excellent Disease Control

Rheumatology congresses post COVID-19: we cannot regress

Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis

All-cause and cause-specific mortality in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: a nationwide registry study

Inflammation and biologic therapy in patients with rheumatoid arthritis achieving versus not achieving ACR/EULAR Boolean remission in a treat-to-target study

Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment

Serious infections in patients with rheumatoid arthritis and psoriatic arthritis treated with tumor necrosis factor inhibitors: data from register linkage of the NOR-DMARD study

Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients with Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial

MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients

Value of MRI and ultrasound for prediction of therapeutic response and erosive progression in patients with early rheumatoid arthritis managed by an aggressive treat-to-target strategy

Conventional versus ultrasound treat to target: No difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis

Achievement of Remission in Two Early Rheumatoid Arthritis Cohorts Implementing Different Treat-to-Target Strategies

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells

Trends in All-Cause and Cardiovascular Mortality in Patients With Incident Rheumatoid Arthritis: A 20-year Follow-Up Matched Case-Cohort Study

Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)

Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis

Subclinical treatment targets in rheumatology: Lessons from randomized clinical trials in rheumatoid arthritis

Immunosuppressive treatment and the risk of diabetes in rheumatoid arthritis

Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial

Predictors of sustained remission in patients with early rheumatoid arthritis treated according to an aggressive treat-to-target protocol

The impact of ultrasound on the use and efficacy of intraarticular glucocorticoid injections in early rheumatoid arthritis: Secondary analyzes from a randomized trial examining the benefit of ultrasound in a clinical tight control regimen

The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy

Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: Associations to future good radiographic and physical outcomes

The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group

Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis

Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria

Ultrasound in the management of rheumatoid arthritis: ARCTIC randomized controlled strategy trial

Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach

Validation of the OMERACT magnetic resonance imaging joint space narrowing score for the wrist in a multireader longitudinal trial

The OMERACT MRI in arthritis working group - Update on status and future research priorities

Rheumatoid arthritis quality measures and radiographic progression

Update on the OMERACT Magnetic Resonance Imaging Task Force: Research and Future Directions

Iterative development and reliability of the OMERACT Hand Osteoarthritis MRI Scoring System

The OMERACT-RAMRIS Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing Score: Intrareader and Interreader Reliability and Agreement with Computed Tomography and Conventional Radiography

Performance of Matrix-Based Risk Models for Rapid Radiographic Progression in a Cohort of Patients With Established Rheumatoid Arthritis

What is the clinical relevance of erosions and joint space narrowing in RA?

Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort

Should modern imaging be part of remission criteria in rheumatoid arthritis?

Update on Research and Future Directions of the OMERACT MRI Inflammatory Arthritis Group

Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System

The OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) Is Reliable and Sensitive to Change: Results from an OMERACT Workshop

Hand osteoarthritis and MRI: development and first validation step of the proposed Oslo Hand Osteoarthritis MRI score

Comparison of utility measures and their relationship with other health status measures in 1041 patients with rheumatoid arthritis

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