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Siri Lillegraven

Senior researcher | Vice President REMEDY

Education

  • Cand.med., University of Oslo (professional study in medicine)
  • Master of Public Health, Harvard School of Public Health
  • Doctoral degree at the Department of Clinical Medicine, University of Oslo

Score

  • Deputy head, Research center for treatment in rheumatology and musculoskeletal diseases (REMEDY), Diakonhjemmet hospital
  • Head of the Unit for Clinical Research, Diakonhjemmet hospital
  • Associate Professor, Department of Health and Society, University of Oslo

Field of interest

  • Clinical studies in orthopedics and rheumatology with a special focus on randomized controlled studies

Other

  • Leader of work package 1 in REMEDY (Treatment studies)
  • Recipient of the Marie Spångberg Award 2022

Email

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Telephone

visiting address

Diakonhjemmet hospital
Forstanderboligen
Reidar Kobros vei 8
0370 Oslo

Postal address

Diakohjemmet hospital
PO Box 23 Vinderen
0319 Oslo

Projects

WP1 - Optimized medical interventions

ARCTIC

Remission in patients with rheumatoid arthritis: a randomized controlled trial investigating the use of ultrasound in clinical follow-up

Project Manager:
Espen A. Haavardsholm
WP1 - Optimized medical interventions

ARCTIC FORWARD

10-year follow-up of patients with rheumatoid arthritis who received structured treatment-to-target therapy in the early disease phase.

Project Manager:
Siri Lillegraven
WP1 - Optimized medical interventions

ARCTIC REWIND

10-year follow-up of patients with rheumatoid arthritis who received structured treatment-to-target therapy in the early disease phase.

Project Manager:
Espen A. Haavardsholm
WP1 - Optimized medical interventions

HIFSAT

Study of surgical approach in hip fracture

Project Manager:
Siri Lillegraven
WP1 - Optimized medical interventions

MethMax

Maximization of treatment effect

Project Manager:
Siri Lillegraven
WP1 - Optimized medical interventions

NORWAY CACTUS

Comparison of treatment strategies in carpal tunnel syndrome

Project Manager:
Hilde Berner Hammer
WP5 - Innovative approaches to remote care

NOR Flare

Distance follow-up of patients with rheumatoid arthritis

Project Manager:
Anne Therese Tveter
WP1 - Optimized medical interventions

NOR Sprint

Follow-up of newly diagnosed patients with psoriatic arthritis with and without imaging

Project Manager:
Siri Lillegraven
WP5 - Innovative approaches to remote care

OA-AID

Digital coping tools and digital follow-up to support joint choice in the treatment of patients with knee osteoarthritis

Project Manager:
Anne Therese Tveter
WP1 - Optimized medical interventions

SQUEEZE

Maximizing the effect of prescription drugs in rheumatoid arthritis 

Project Manager:
Espen A. Haavardsholm

Publications

Publications taken from the National Science Archive (NVA):

Effects of tapering conventional synthetic disease-modifying antirheumatic drugs to drug-free remission versus stable treatment in rheumatoid arthritis (ARCTIC REWIND): 3-year results from an open-label, randomized controlled, non-inferiority trial

Kaja Eriksrud Kjørholt, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Hallvard Fremstad


The Lancet Rheumatology

2024

Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity

Karen Holten, Nina Paulshus Sundlisæter, Joseph Sexton, Lena Bugge Nordberg, Till Uhlig, Tore Kristian Aaserud Kvien


RMD Open

2024

Use of direct-acting anticoagulants (DOACs) delays surgery and is associated with increased mortality in hip fracture patients

Mads Sundet, Ulf Gunnar Sundin, Aasmund Godø, Kristian Sydnes, Haldor Valland, Joseph Sexton


European Journal of Trauma and Emergency Surgery

2024

Follow-Up of Patients With Axial Spondyloarthritis in Specialist Health Care With Remote Monitoring and Self-Monitoring Compared With Regular Face-to-Face Follow-Up Visits (the ReMonit Study): Protocol for a Randomized, Controlled Open-Label Noninferiority Trial

Inger Jorid Berg, Anne Therese Tveter, Gunnstein Bakland, Sarah Hakim, Eirik Kristianslund, Siri Lillegraven


JMIR Research Protocols

2023

Effect of tapered versus stable treatment with tumor necrosis factor inhibitors on disease flares in patients with rheumatoid arthritis in remission: a randomised, open label, non-inferiority trial

Siri Lillegraven, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Åse Lexberg


Annals of the Rheumatic Diseases

2023

Discontinuation of Conventional Synthetic Disease-Modifying Antirheumatic Drugs in Patients with Rheumatoid Arthritis and Excellent Disease Control

Siri Lillegraven, Nina Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Daniel H. Solomon, Désirée Van Der Heijde


Journal of the American Medical Association (JAMA)

2023

Identification of SNPs associated with methotrexate treatment outcomes in patients with early rheumatoid arthritis

Shrikant Kolan, Gaoyang Li, Franco Grimolizzi, Joseph Sexton, Tore Kristian Kvien, Guro Løvik Goll


Frontiers in Pharmacology

2022

All-cause and cause-specific mortality in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: a nationwide registry study

Anne Mirjam Kerola, Amirhossein Kazemi, Silvia Christin Hellerud Rollefstad, Siri Lillegraven, Joseph Sexton, Grunde Wibetoe


Rheumatology

2022

Inflammation and biologic therapy in patients with rheumatoid arthritis achieving versus not achieving ACR/EULAR Boolean remission in a treat-to-target study

Nina Beate Paulshus Sundlisæter, Ulf Gunnar Sundin, Anna-Birgitte Aga, Joseph Sexton, Hilde Berner Hammer, Till Uhlig


RMD Open

2022

Fatigue in patients with early rheumatoid arthritis undergoing treat-to-target therapy: predictors and response to treatment

Karen Holten, Nina Beate Paulshus Sundlisæter, Siri Lillegraven, Joseph Sexton, Lena Kristine Bugge Nordberg, Ellen Moholt


Annals of the Rheumatic Diseases

2021

Serious infections in patients with rheumatoid arthritis and psoriatic arthritis treated with tumor necrosis factor inhibitors: data from register linkage of the NOR-DMARD study

Ingrid Egeland Christensen, Siri Lillegraven, Mielnik Pawel, Gunnstein Bakland, Liz Paucar Loli, Joseph Sexton


Annals of the Rheumatic Diseases

2021

Effect of Half-Dose vs Stable-Dose Conventional Synthetic Disease-Modifying Antirheumatic Drugs on Disease Flares in Patients with Rheumatoid Arthritis in Remission: The ARCTIC REWIND Randomized Clinical Trial

Siri Lillegraven, Nina Beate Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Hallvard Fremstad


Journal of the American Medical Association (JAMA)

2021

MicroRNA Expression Differences in Blood-Derived CD19+ B Cells of Methotrexate Treated Rheumatoid Arthritis Patients

Fatima Heinicke, Xiangfu Zhong, Siri Tennebø Flåm, Johannes Breidenbach, Magnus Leithaug, Marthe Thoresen Mæhlen


Frontiers in Immunology

2021

Value of MRI and ultrasound for prediction of therapeutic response and erosive progression in patients with early rheumatoid arthritis managed by an aggressive treat-to-target strategy

Ulf Gunnar Sundin, Nina Beate Paulshus Sundlisæter, Anna-Birgitte Aga, Joseph Sexton, Lena Kristine Bugge Nordberg, Hilde Berner Hammer


RMD Open

2021

Conventional versus ultrasound treat to target: No difference in magnetic resonance imaging inflammation or joint damage over 2 years in early rheumatoid arthritis

Ulf Gunnar Sundin, Anna-Birgitte Aga, Øivind Skare, Lena Kristine Bugge Nordberg, Till Uhlig, Hilde Berner Hammer


Rheumatology

2020

Achievement of Remission in Two Early Rheumatoid Arthritis Cohorts Implementing Different Treat-to-Target Strategies

Vibeke Norvang, Gina Charlotte Hetland Brinkmann, Kazuki Yoshida, Siri Lillegraven, Anna-Birgitte Aga, Joseph Andrew Sexton


Arthritis & Rheumatology

2020

Rheumatoid Arthritis Patients, Both Newly Diagnosed and Methotrexate Treated, Show More DNA Methylation Differences in CD4+ Memory Than in CD4+ Naïve T Cells

Kari Guderud, Line Hagen Sunde, Siri Tennebø Flåm, Marthe Thoresen Mæhlen, Maria Dahl Mjaavatten, Siri Lillegraven


Frontiers in Immunology

2020

Trends in All-Cause and Cardiovascular Mortality in Patients With Incident Rheumatoid Arthritis: A 20-year Follow-Up Matched Case-Cohort Study

Sella Aarrestad Provan, Siri Lillegraven, Joseph Sexton, Kristin Angel, Cathrine Austad, Espen A. Haavardsholm


Rheumatology

2019

Validity and responsiveness of combined inflammation and combined joint damage scores based on the OMERACT rheumatoid arthritis MRI scoring system (RAMRIS)

Ulf Gunnar Sundin, Mikkel Østergaard, Daniel Glinatsi, Anna-Birgitte Aga, Kim Hørslev-Petersen, Merete L. Hetland


Journal of Rheumatology

2019

Peptidylarginine deiminase 4 (PAD4) activity in early rheumatoid arthritis

Maria Karolina Jonsson, Tomasz Tadeusz Kantyka, Katherine Falkowski, Ardita Aliko, Anna-Birgitte Aga, Siri Lillegraven


Scandinavian Journal of Rheumatology

2019

Subclinical treatment targets in rheumatology: Lessons from randomized clinical trials in rheumatoid arthritis

Siri Lillegraven, Espen A. Haavardsholm


Rheumatic Disease Clinics of North America

2019

Immunosuppressive treatment and the risk of diabetes in rheumatoid arthritis

Siri Lillegraven, Jeffrey D. Greenberg, George W. Reed, Katherine Saunders, Jeffrey R. Curtis, Leslie Harrold


PLOS ONE

2019

Comparing the disease course of patients with seronegative and seropositive rheumatoid arthritis fulfilling the 2010 ACR/EULAR classification criteria in a treat-to-target setting: 2-year data from the ARCTIC trial

Lena Kristine Bugge Nordberg, Siri Lillegraven, Anna-Birgitte Aga, Joseph Sexton, Inge Christoffer Olsen, Elisabeth Lie


RMD Open

2018

Predictors of sustained remission in patients with early rheumatoid arthritis treated according to an aggressive treat-to-target protocol

Nina Beate Paulshus Sundlisæter, Inge Christoffer Olsen, Anna-Birgitte Aga, Hilde Berner Hammer, Till Uhlig, Desirée van der Heijde


Rheumatology

2018

The impact of ultrasound on the use and efficacy of intraarticular glucocorticoid injections in early rheumatoid arthritis: Secondary analyzes from a randomized trial examining the benefit of ultrasound in a clinical tight control regimen

Lena Kristine Bugge Nordberg, Siri Lillegraven, Anna-Birgitte Aga, Joseph Sexton, Elisabeth Lie, Hilde Berner Hammer


Arthritis & Rheumatology

2018

The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy

Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm


Arthritis Research & Therapy

2018

Clinical and ultrasound remission after 6 months of treat-to-target therapy in early rheumatoid arthritis: Associations to future good radiographic and physical outcomes

Nina Beate Paulshus Sundlisæter, Anna-Birgitte Aga, Inge Christoffer Olsen, Hilde Berner Hammer, Till Uhlig, Desirée van der Heijde


Annals of the Rheumatic Diseases

2018

The OMERACT Rheumatoid Arthritis Magnetic Resonance Imaging (MRI) Scoring System: Updated Recommendations by the OMERACT MRI in Arthritis Working Group

Mikkel Østergaard, Charles G. Peterfy, Paul Bird, Frédérique Gandjbakhch, Daniel Glinatsi, Iris Eshed


Journal of Rheumatology

2017

Calprotectin as a marker of inflammation in patients with early rheumatoid arthritis

Maria Karolina Jonsson, Nina Beate Paulshus Sundlisæter, Hilde Haugedal Nordal, Hilde Berner Hammer, Anna-Birgitte Aga, Inge Christoffer Olsen


Annals of the Rheumatic Diseases

2017

Patients with seronegative RA have more inflammatory activity compared with patients with seropositive RA in an inception cohort of DMARD-naïve patients classified according to the 2010 ACR/EULAR criteria

Lena Kristine Bugge Nordberg, Siri Lillegraven, Elisabeth Lie, Anna-Birgitte Aga, Inge Christoffer Olsen, Hilde Berner Hammer


Annals of the Rheumatic Diseases

2017

Ultrasound in the management of rheumatoid arthritis: ARCTIC randomized controlled strategy trial

Espen A. Haavardsholm, Anna-Birgitte Aga, Inge Christoffer Olsen, Siri Lillegraven, Hilde Berner Hammer, Till Uhlig


The BMJ

2016

Development of a feasible and responsive ultrasound inflammation score for rheumatoid arthritis through a data-driven approach

Anna-Birgitte Aga, Hilde Berner Hammer, Inge Christoffer Olsen, Till Uhlig, Tore Kristian Kvien, Desirée van der Heijde


RMD Open

2016

Validation of the OMERACT magnetic resonance imaging joint space narrowing score for the wrist in a multireader longitudinal trial

Daniel Glinatsi, Siri Lillegraven, Espen A. Haavardsholm, Iris Eshed, Philip G. Conaghan, Charles Peterfy


Journal of Rheumatology

2015

The OMERACT MRI in arthritis working group - Update on status and future research priorities

Mikkel Østergaard, Paul Bird, Frédérique Gandjbakhch, Iris Eshed, Ida Kristin Haugen, Espen Haavardsholm


Journal of Rheumatology

2015

Rheumatoid arthritis quality measures and radiographic progression

Sonali P Desai, Chih-Chin Liu, Heather Tory, Tabatha Norton, Michelle L Frits, Siri Lillegraven


Seminars in Arthritis & Rheumatism

2014

Update on the OMERACT Magnetic Resonance Imaging Task Force: Research and Future Directions

Philip G. Conaghan, Fiona M. McQueen, Paul Bird, Charles G. Peterfy, Espen A. Haavardsholm, Frédérique Gandjbakhch


Journal of Rheumatology

2014

Iterative development and reliability of the OMERACT Hand Osteoarthritis MRI Scoring System

Ida Kristin Haugen, Mikkel Østergaard, Iris Eshed, Fiona M. McQueen, Paul Bird, Frédérique Gandjbakhch


Journal of Rheumatology

2014

The OMERACT-RAMRIS Rheumatoid Arthritis Magnetic Resonance Imaging Joint Space Narrowing Score: Intrareader and Interreader Reliability and Agreement with Computed Tomography and Conventional Radiography

Uffe Møller Døhn, Philip G. Conaghan, Iris Eshed, Annelies Boonen, Pernille Helen Bøyesen, Charles G. Peterfy


Journal of Rheumatology

2013

Performance of Matrix-Based Risk Models for Rapid Radiographic Progression in a Cohort of Patients With Established Rheumatoid Arthritis

Siri Lillegraven, Nina Paynter, Femke HM Prince, Nancy Shadick, Espen A. Haavardsholm, Michelle L Frits


Arthritis Care and Research

2013

What is the clinical relevance of erosions and joint space narrowing in RA?

Siri Lillegraven, Desirée van der Heijde, Till Uhlig, Tore Kristian Kvien, Espen A. Haavardsholm


Nature Reviews Rheumatology

2012

Remission and radiographic outcome in rheumatoid arthritis: application of the 2011 ACR/EULAR remission criteria in an observational cohort

Siri Lillegraven, Femke HM Prince, Nancy Shadick, Vivian P. Bykerk, Bing Lu, Michelle L Frits


Annals of the Rheumatic Diseases

2012

Should modern imaging be part of remission criteria in rheumatoid arthritis?

Espen A. Haavardsholm, Elisabeth Lie, Siri Lillegraven


Baillière's Best Practice & Research : Clinical Rheumatology

2012

Update on Research and Future Directions of the OMERACT MRI Inflammatory Arthritis Group

Philip G. Conaghan, Fiona M. McQueen, Paul Bird, Charles G. Peterfy, Espen A. Haavardsholm, Frédérique Gandjbakhch


Journal of Rheumatology

2011

Development and Preliminary Validation of a Magnetic Resonance Imaging Joint Space Narrowing Score for Use in Rheumatoid Arthritis: Potential Adjunct to the OMERACT RA MRI Scoring System

Mikkel Østergaard, Pernille Helen Bøyesen, Iris Eshed, Frédérique Gandjbakhch, Siri Lillegraven, Paul Bird


Journal of Rheumatology

2011

The OMERACT Psoriatic Arthritis Magnetic Resonance Imaging Score (PsAMRIS) Is Reliable and Sensitive to Change: Results from an OMERACT Workshop

Pernille Helen Bøyesen, Fiona M. McQueen, Frédérique Gandjbakhch, Siri Lillegraven, Laura Coates, Charlotte Wiell


Journal of Rheumatology

2011

Hand osteoarthritis and MRI: development and first validation step of the proposed Oslo Hand Osteoarthritis MRI score

Ida Kristin Haugen, Siri Lillegraven, Barbara Therese Slatkovsky Christensen, Espen A. Haavardsholm, Tore Kristian Kvien, Desirée van der Heijde


Annals of the Rheumatic Diseases

2011

Comparison of utility measures and their relationship with other health status measures in 1041 patients with rheumatoid arthritis

Siri Lillegraven, Ivar Sønbø Kristiansen, Tore Kristian Kvien


Annals of the Rheumatic Diseases

2010