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Nor-Hand

Longitudinal observational study of people with hand osteoarthritis

Project Manager
Rheumatologist | PhD

Ida K. Bos-Haugen, senior researcher

Post doc
Rheumatologist | PhD

Pernille S. Pettersen


Physiotherapist (PhD)

Elisabeth Mulrooney


Doctor

Marthe Gløersen

PhD fellow
Physical therapist

Daniel Huseby Bordvik

ABOUT THE PROJECT

Hand osteoarthritis is a disease that affects a large proportion of the population, and particularly women. Hand osteoarthritis can cause significant discomfort in the form of pain, reduced function and stiffness. There is currently no treatment that can prevent or delay the development of the disease.

The project's goal is to better understand the causes of pain in people with hand osteoarthritis, and study various disease markers, such as imaging and patient-reported outcome measures. In the long term, this will provide a better basis for relieving patients' pain and increasing knowledge about underlying disease mechanisms.

WHO CAN JOIN?

The study includes adult patients with hand osteoarthritis who have been referred to or are being followed at the rheumatology outpatient clinic at Diakonhjemmet Hospital.

Recruitment of new participants in the study has been completed.

WHAT DOES THE STUDY INVOLVE?

Participants were examined at two time points (2016-17 and 2019-21). 300 patients completed the examinations in 2016-17, while 213 participated in 2019-21 (of which 206 completed the clinical examination).

The participants have filled out various questionnaires, undergone a clinical examination, completed tests to assess pain sensitivity, taken blood samples and provided a urine sample, and had various imaging examinations such as X-rays, MRIs and ultrasounds.

PUBLICATIONS

Items 1-19 of 19 ( Display the 19 citations in PubMed )

1.

Hand osteoarthritis phenotypes based on a biopsychosocial approach, and their associations with cross-sectional and longitudinal pain.

Mulrooney E, Neogi T, Dagfinrud H, Hammer HB, Pettersen PS, Kvien TK, Magnusson K, Haugen IK.

Osteoarthritis Cartilage. 2024 Apr 30:S1063-4584(24)01168-3. doi: 10.1016/j.joca.2024.04.011. Online ahead of print.

PMID: 38697510

2.

Associations between pain sensitization and measures of physical function in people with hand osteoarthritis: Results from the Nor-Hand study.

Gløersen M, Steen Pettersen P, Neogi T, Sexton J, Kvien TK, Hammer HB, Haugen IK.

Osteoarthritis Cartilage. 2023 Oct;31(10):1388-1395. doi: 10.1016/j.joca.2023.07.005. Epub 2023 Jul 24.

PMID: 37495183

3.

Comorbidities in people with hand OA and their associations with pain severity and sensitization: Data from the longitudinal Nor-Hand study.

Mulrooney E, Neogi T, Dagfinrud H, Hammer HB, Pettersen PS, Gløersen M, Kvien TK, Magnusson K, Haugen IK.

Osteoarthr Cartil Open. 2023 May 5;5(3):100367. doi: 10.1016/j.ocarto.2023.100367. eCollection 2023 Sep.

PMID: 37234862 Free PMC article.

4.

The associations of psychological symptoms and cognitive patterns with pain and pain sensitization in people with hand osteoarthritis.

Mulrooney E, Neogi T, Dagfinrud H, Hammer HB, Pettersen PS, Gaarden TL, Engedal K, Kvien TK, Magnusson K, Haugen IK.

Osteoarthr Cartil Open. 2022 May 6;4(2):100267. doi: 10.1016/j.ocarto.2022.100267. eCollection 2022 Jun.

PMID: 36475288 Free PMC article.

5.

Characteristics of persons with hand osteoarthritis visiting complementary and alternative medicine providers.

Ulrichsen M, Kristoffersen AE, Kjeken I, Haugen IK.

Osteoarthr Cartil Open. 2021 Nov 17;3(4):100220. doi: 10.1016/j.ocarto.2021.100220. eCollection 2021 Dec.

PMID: 36474754 Free PMC article.

6.

Associations of Body Mass Index With Pain and the Mediating Role of Inflammatory Biomarkers in People With Hand Osteoarthritis.

Gløersen M, Steen Pettersen P, Neogi T, Jafarzadeh SR, Vistnes M, Thudium CS, Bay-Jensen AC, Sexton J, Kvien TK, Hammer HB, Haugen IK.

Arthritis Rheumatol. 2022 May;74(5):810-817. doi: 10.1002/art.42056. Epub 2022 Mar 23.

PMID: 35137553 Free PMC article.

7.

Associations of pain sensitization with tender and painful joint counts in people with hand osteoarthritis: results from the Nor-Hand study.

Gløersen M, Steen Pettersen P, Neogi T, Slatkowsky-Christensen B, Kvien TK, Magnusson K, Hammer HB, Haugen IK.

RMD Open. 2022 Jan;8(1):e001774. doi: 10.1136/rmdopen-2021-001774.

PMID: 34987090 Free PMC article.

8.

Associations between joint pathologies and central sensitization in persons with hand osteoarthritis: results from the Nor-Hand study.

Steen Pettersen P, Neogi T, Magnusson K, Mathiessen A, Hammer HB, Uhlig T, Kvien TK, Haugen IK.

Rheumatology (Oxford). 2022 May 30;61(6):2316-2324. doi: 10.1093/rheumatology/keab708.

PMID: 34559196 Free PMC article.

9.

Study protocol for the follow-up examination of the Nor-Hand study: A hospital-based observational cohort study exploring pain and biomarkers in people with hand osteoarthritis.

Gløersen M, Steen Pettersen P, Maugesten Ø, Mulrooney E, Mathiessen A, Gammelsrud H, Hammer HB, Neogi T, Ohrndorf S, Faraj K, Sjølie D, Slatkowsky-Christensen B, Kvien TK, Haugen IK.

Osteoarthr Cartil Open. 2021 Jul 30;3(3):100198. doi: 10.1016/j.ocarto.2021.100198. eCollection 2021 Sep.

PMID: 36474811 Free PMC article.

10.

Reliability and agreement of proton density-weighted vs. gadolinium-enhanced T1-weighted MRI in hand osteoarthritis. An OMERACT MRI special interest group reliability exercise.

Maugesten Ø, Pedersen SJ, Stoenoiu MS, Kroon F, Mathew AJ, Genant HK, Conaghan PG, Gandjbakhch F, Kloppenburg M, Peterfy C, Østergaard M, Haugen IK.

Semin Arthritis Rheum. 2021 Aug;51(4):929-932. doi: 10.1016/j.semarthrit.2021.05.007. Epub 2021 May 21.

PMID: 34140182

11.

Associations between fluorescence optical imaging and magnetic resonance imaging and symptoms in hand osteoarthritis.

Maugesten Ø, Ohrndorf S, Slatkowsky-Christensen B, Kvien TK, Uhlig T, Haugen IK.

Rheumatology (Oxford). 2022 Feb 2;61(2):764-769. doi: 10.1093/rheumatology/keab085.

PMID: 33521807

12.

Validity and diagnostic performance of fluorescence optical imaging measuring synovitis in hand osteoarthritis: baseline results from the Nor-Hand cohort.

Maugesten Ø, Mathiessen A, Hammer HB, Hestetun SV, Kvien TK, Uhlig T, Ohrndorf S, Haugen IK.

Arthritis Res Ther. 2020 May 1;22(1):98. doi: 10.1186/s13075-020-02185-0.

PMID: 32357904 Free PMC article.

13.

Evaluation of three scoring methods for Fluorescence Optical Imaging in erosive hand osteoarthritis and rheumatoid arthritis.

Maugesten Ø, Ohrndorf S, Glinatsi D, Ammitzbøll-Danielsen M, Kisten Y, Østergaard M, Terslev L, Uhlig T, Kvien TK, Haugen IK.

Osteoarthr Cartil Open. 2019 Dec 9;1(3-4):100017. doi: 10.1016/j.ocarto.2019.100017. eCollection 2020 Jan-Feb.

PMID: 36475004 Free PMC article.

14.

Get a Grip on Factors Related to Grip Strength in Persons With Hand Osteoarthritis: Results From an Observational Cohort Study.

Haugen IK, Aaserud J, Kvien TK.

Arthritis Care Res (Hoboken). 2021 Jun;73(6):794-800. doi: 10.1002/acr.24385.

PMID: 32702166

15.

Associations Between Radiographic and Ultrasound-Detected Features in Hand Osteoarthritis and Local Pressure Pain Thresholds.

Steen Pettersen P, Neogi T, Magnusson K, Hammer HB, Uhlig T, Kvien TK, Haugen IK.

Arthritis Rheumatol. 2020 Jun;72(6):966-971. doi: 10.1002/art.41199. Epub 2020 Apr 26.

PMID: 31904188 Free PMC article.

16.

Associations Between Ultrasound-Detected Synovitis, Pain, and Function in Interphalangeal and Thumb Base Osteoarthritis: Data From the Nor-Hand Cohort.

Fjellstad CM, Mathiessen A, Slatkowsky-Christensen B, Kvien TK, Hammer HB, Haugen IK.

Arthritis Care Res (Hoboken). 2020 Nov;72(11):1530-1535. doi: 10.1002/acr.24047.

PMID: 31421023

17.

Validation of the Intermittent and Constant Osteoarthritis Pain Questionnaire in Patients with Hand Osteoarthritis: Results from the Nor-Hand Study.

Gløersen M, Steen Pettersen P, Kvien TK, Haugen IK.

J Rheumatol. 2019 Jun;46(6):645-651. doi: 10.3899/jrheum.180835. Epub 2019 Mar 15.

PMID: 30877221

18.

Peripheral and Central Sensitization of Pain in Individuals With Hand Osteoarthritis and Associations With Self-Reported Pain Severity.

Steen Pettersen P, Neogi T, Magnusson K, Berner Hammer H, Uhlig T, Kvien TK, Haugen IK.

Arthritis Rheumatol. 2019 Jul;71(7):1070-1077. doi: 10.1002/art.40850. Epub 2019 May 14.

PMID: 30741501 Free PMC article.

19.

A hospital-based observational cohort study exploring pain and biomarkers in patients with hand osteoarthritis in Norway: The Nor-Hand protocol.

Gløersen M, Mulrooney E, Mathiessen A, Hammer HB, Slatkowsky-Christensen B, Faraj K, Isaksen T, Neogi T, Kvien TK, Magnusson K, Haugen IK.

BMJ Open. 2017 Sep 24;7(9):e016938. doi: 10.1136/bmjopen-2017-016938.

PMID: 28947452 Free PMC article.
20.

The associations between sleep problems and pain outcomes in people with hand osteoarthritis - Data from the Nor-hand study - PubMed (nih.gov)

Bordvik DH, Steen Pettersen P, Gløersen M, Mulrooney E, Neogi T, Kjeken I, Haugen IK.

Osteoarthr Cartil Open. 2025 Feb 5;7(1):100579. doi: 10.1016/j.ocarto.2025.100579. eCollection 2025 Mar.

PMID: 40034602